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After administration of losartan for 2 weeks and 12 weeks, 24-hour urinary protein excretion (24 hUPE), Scr and Ccr were measured, and renal morphology was observed. 分别于2周和12周杀鼠,观察体重、肾重、肾重/体重指数、尿蛋白量(24 h)、Scr、Ccr以及肾组织病理改变;