major breakdown

基本解释

A colleague of Godiwalla's who worked in M&A had a major breakdown.
高笛瓦勒的一位在企业并购部门工作的同事受到了重大打击。
When a major mechanical breakdown occurs it can cost the homeowner thousands of dollars.
当发生重大机械故障可以成本房主几千美元。
At the same time, with their forces mere miles apart, a major breakdown over Mr. Karlov's assassination would simply be too dangerous to tolerate.
与此同时，鉴于双方的部队仅相距数英里，因卡尔洛夫遇刺一事而导致关系严重破裂这种情况实在太危险，两国都无法容忍。

Moreover, after a major breakdown in multilateral trade talks in Germany earlier this month, the stalled Doha Round of trade negotiations looks all but dead.
FORBES: Fast Track To Nowhere
Since then, it's shown no major breakdown of relative strength.
FORBES: Magazine Article
Repairs are usually quick and easy, but it becomes obvious that should there be a major breakdown, business routine could be thrown into chaos, since by no stretch of imagination could the staff make up for the work lost on the computor.
ECONOMIST: The business world