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After administration of losartan for 2 weeks and 12 weeks, 24-hour urinary protein excretion (24 hUPE), Scr and Ccr were measured, and renal morphology was observed. 分別於2周和12周殺鼠,觀察躰重、腎重、腎重/躰重指數、尿蛋白量(24 h)、Scr、Ccr以及腎組織病理改變;